Dr. Guyette has spent over 20 years in EMS and has devoted his academic career to EMS research and management. He received his MD from Tulane University and completed residency, fellowship, and public health training at the University of Pittsburgh. As the Medical Director for the nations largest non-profit critical care transport group, the advancement of evidenced based patient care is one of his core goals. Frank has examined prehospital care and safety with funding from the National Association of EMS physicians, the United States Air Force, and the Foundation for Air Medical Research and Education (now the Medevac Foundation). Dr. Guyette has been recognized as one of the Journal of Emergency Medical Services "EMS 10: Innovators in EMS" and as the recipient of the Barbara A. Hess Award for Research and Education by the Association of Air Medical Services.

Dr. Guyette studies prehospital resuscitation medicine with special emphasis on traumatic shock and cardiac arrest. He has developed a research program to study air medical transport of critically ill patients. The program is designed to develop evidence-based principles for the monitoring and treatment of patients during critical care transport. Collaborating with physicians from emergency medicine, trauma surgery and critical care medicine, he has studied prehospital airway management, point of care testing of lactate, and tissue oximetry to identify shock. Dr. Guyette is also active in prehospital workforce protection, participating in studies on the effects of sleep, heat stress, and teamwork. These efforts have resulted in studies addressing sleep quality and fatigue in air medical providers, the effects of heat stress on the performance of providers, and the effect of teamwork on the incidence of adverse events.